Envisioning life-changing therapies for neurodegenerative and other diseases

What we do

Our approach

Eikonizo is developing disease-modifying therapies by creating brain penetrant and peripheral small molecules to improve the lives of people impacted by neurodegenerative, cardiorenal and other diseases.

Our Programs

Eikonizo is developing a pipeline of highly selective small molecule inhibitors of HDAC6, a cytoplasmic lysine deacetylase

Our Programs

Eikonizo is developing a pipeline of highly selective small molecule inhibitors of HDAC6, a cytoplasmic lysine deacetylase

Dual Mechanism

HDAC6 inhibitor treatment improves intracellular transport and reduces protein aggregates to help cells survive and function, without the side effects associated with previous generation compounds targeting HDACs

Dual Mechanism

HDAC6 inhibitor treatment improves intracellular transport and reduces protein aggregates to help cells survive and function, without the side effects associated with previous generation compounds targeting HDACs
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Supporting Literature

Compelling evidence supports Eikonizo’s unique approach to HDAC6 inhibition

Supporting Literature

Compelling evidence supports Eikonizo’s unique approach to HDAC6 inhibition
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electron microscopic view
Mechanistically Based

Therapeutic Development

Eikonizo’s unique approach to HDAC6 inhibition is designed to synergistically target the dual mechanisms of intracellular transport and proteostasis (protein homeostasis), two key drivers of neurodegenerative and cardiorenal disease biology.

Inhibiting HDAC6 in the brain and peripheral nervous system will preserve axonal transport (intracellular transport in the axons of nerve cells) and reduce aberrant protein aggregation which together may slow or stop the progression of neurodegenerative disease.

HDAC6 inhibition may also impact the course of peripheral indications such as cardiorenal disease by improving both intracellular transport and proteostasis or autophagy defects in kidney, cardiac and other cells.

These dual mechanisms also improve other common pathological disease processes including chronic inflammation, mitochondrial dysfunction and oxidative stress leading to overall improvements in cellular health and function.

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