Therapeutic
Hypothesis

Mechanistic Rationale

HDAC6 inhibitor treatment will preserve axonal transport and stop or slow the progression of ALS and AD

HDAC6 inhibitor treatment will prevent tau aggregation and stop or slow the progression of AD

Mechanistic Rationale

HDAC6 inhibitor treatment will preserve axonal transport and stop or slow the progression of ALS and AD

HDAC6 inhibitor treatment will prevent tau aggregation and stop or slow the progression of AD

Healthy & Dysfunctional Neurons
HDAC6 inhibitor treatment will preserve axonal transport and stop or slow the progression of ALS and AD
HEALTHY NEURONS
therapeutic hypothesis neuron

Neurons contain microtubules, which perform important transport functions.

HEALTHY NEURONS
therapeutic hypothesis neuron

Acetylated tau and tubulin proteins provide structure to microtubules and support axonal transport

Dysfunctional Neurons
therapeutic hypothesis neuron

HDAC6 deacetylates tau and tubulin, which makes microtubules less resilient and axonal transport is disrupted.

Healthy & Dysfunctional Neurons
HDAC6 Inhibitor Treatment Will Prevent Tau Aggregation And Stop Or Slow The Progression Of AD​
therapeutic hypothesis neuron

Neurons contain microtubules, which perform important transport functions

therapeutic hypothesis neuron

Acetylated tau proteins provide structure to microtubules and support axonal transport.

therapeutic hypothesis molecules

HDAC6 deacetylates tau, which becomes unbound from microtubules. Free tau becomes phosphorylated.

therapeutic hypothesis neuron

Eventually, tau becomes hyper-phosphorylated, which leads to neurofibrillary tangles(NFTs).

therapeutic hypothesis neuron

Tangles accumulate within neurons, microtubules fail to function and eventually neurons die.